Owens DR, Zinman B, Bolli G
This inflammation is the very thing we are trying to treat
MRI: magnetic resonance imaging Mechanisms of muscle loss associated with GLP-1RAs treatment Preservation of skeletal muscle is critical for metabolic health, physical function and long-term outcomes, making the study of mechanisms underlying muscle loss during GLP-1RA therapy clinically relevant
Timing and Circadian Effects The pituitary also has intrinsic rhythmicity and responsiveness that varies throughout the day and in different metabolic states - somatotrophs are more responsive to GHRH stimulation during certain circadian phases (particularly during sleep), after exercise, during fasting, and in the presence of ghrelin (the "hunger hormone" that synergizes with GHRH to amplify GH release)
Funding: Research reported in this publication was supported by the National Center For Advancing Translational Sciences of the National Institutes of Health under Award Number KL2TR001856 and the National Institute of Diabetes and Digestive and Kidney Diseases (Luo) under Award Number K23DK120956